Which of the following effects is an acidic drug such as aspirin likely to produce in the body?

Select one:

a. No change due to downregulation of the number of transporters for tubular secretion

b. No change due to upregulation in the number of transporters for tubular secretion

c. Metabolic alkalosis due to limited number of transporters for tubular secretion

d. Metabolic acidosis due to limited number of transporters for tubular secretion