What is the mechanism of Synthesis of Zyban (Wellbutrin, Bupropion). In this experiment zyban was synthesized from propiophenone through an acid catalyzed bromination. The brominated product then underwent a substitution, losing a bromine and gaining a tert-butylamine, to form the Zyban free base. 2M acetyl chloride/isopropyl alcohol was then added to the free base to form Zyban in the presence of HCL salt. And what would be the theoretical yield