How to Prepare the REVIEW of the article “ The p53 Orchestra….”

• Read the scientific article. Make notes summarizing key ideas and noting critical portions of the text.
• The review should be 5 pages, single-spaced or 1.5 spaces using a standard 12-point font (such as Times New Roman).
• As before, please include NO MORE THAN 1 FIGURE.
• Please address the following points in your review:
  • In 300-500 describe the process of UBIQUITINATION. What is E1, E2 & E3? What is the role of Mdm2 and/or Mdmx in the process?
  • What is the role that Mdm2 and Mdmx play in p53 stability? Be as detailed as you can.
  • Discuss, briefly, the multiple cell signaling cascades that converge on Mdm2 and Mdmx (Figure 4).