At least 150-word response to each question. Each response must have at least 1 Reference within the past 5 years. APA format

1). What safety or efficacy issues exist with estroen replacement therapies?  That is, are there any concerns with use of such therapies?  If so, what are these concerns, and how can these concerns be mitigated?  If not, explain why these therapies may have few concerns of use.

2). Should the patient have an elevated PSA or abnormal DRE, what further actions should be taken?  That is, what next step would be most appropriate?