1. 1)Using the principles of pharmacokinetics, describe the journey of a orally administered drug starting with the moment the drug is swallowed.  Then compare that process with a medication that is administered intravenously.

2)You are intending to prescribe your patient 2 medications: drug X and drug Y.  The patient is a 77-year-old female with a past medical history of type-2 diabetes, hypertension, and CKD III-IV.  She recently had geriatric pharmacogenomic testing done and was found to have a hyperactive CYP 3A4 gene presentation (which is sometimes referred to as an extensive or hyper metabolizer).  You see that drug X is almost exclusively renally cleared.  You also see that drug Y is extensively hepatically metabolized.  Based on this info, what would you expect in terms of blood concentrations of both drugs after administration?  Would you think any dose adjustments would be necessary, and if so how might you adjust them?