LIST METHODS WHICH HAVE BEEN USED FOR THE TREATMENT OF CANCER BY HYPERTHERMIA.Discuss the biological effects of heat on cells, and compare/contrast cell killing by heat
and ionising radiation.

1 List methods which have been used for the treatment of cancer by hyperthermia.
Discuss the biological effects of heat on cells, and compare/contrast cell killing by heat
and ionising radiation.
2 A 120 kg male has had 4 separate fluoroscopic cardiac interventional procedures over
the past week. The beam used wide field imaging at 120kv, averaging 30 minutes
beam on time per exposure at 0.2 gray per minute. How should this man be counselled
on all the relevant effects from his absorbed dose? Outline the radiobiology of acute
human skin reactions (timing, cellular changes and gross skin changes).
3 Discuss the relevance of tumour hypoxia in current Radiation Oncology practice.
4 Describe the mammalian cell cycle, emphasising its main components and the
molecules and processes which both regulate, and are regulated, during the cycle.
What changes can ionising radiation induce in the cell cycle?
5 Write short notes on any three of the following:
a) Rationale for post-operative irradiation
b) The significance of chromosome aberrations following irradiation
c) CHART
d) Potentially lethal damage and its repair

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