How would you evaluate and manage a pediatric patient who has a painful swelling of the hands and feet, fatigue, or fussiness?

Which diagnostic studies would you recommend for a pediatric patient with painful swelling hands and feet?

What physical exam findings and diagnostic results would be concerning?

In sickle cell disorder (SCD), the spleen doesn’t work properly or doesn’t work at all. This problem makes people with SCD more likely to get severe infections. What is the treatment for SCD and education for the family?