A system has 1010 binding sites for a protein. Of these sites, 104 are originally filled. The system moves to a new arrangement in which 10^3 sites are filled. What is the change in entropy between these two binding arrangements? Answer will be exact.

a)    -1.92 X 10-19 J/K

b)    -1.81 X 10-18 J/K

c)    -1.41 X 10-19 J/K

d)    -1.23 X 10-18 J/K

e)    -8.62 X 10-18 J/K