68. A new variety of mushroom was isolated in your lab and you noticed that when extracts of the mushroom were added to bacterial cultures, growth was halted. You suspected that the extract contained a new derivative of amanitin. You then confirmed this by showing that :
A. Cells treated with the new compound expressed a specific gene you were studying, but not its corresponding protein.
B. Eukaryotic cell growth was accelerated by the compound.
C. When added to eukaryotic cell, both transcription was halted as well as protein production.
D. The compound could bind to the transcription factor TFIID
E. All of the above.
69. The new form of amanitin was used by you in an experiment where cells treated with prolactin were examined for the expression of a casein gene. The results showed that casein mRNA, whose expression was induced when exposed to prolactin, was no longer detectable when both prolactin and the new form of amanitin were added together. This showed that:
A. Casein was degraded by the new actinomycin D compound.
B. Casein protein was not produced by the cell.
C. Casein is a potent antibiotic.
D. Casein mRNA regulation by prolactin was possibly a direct transcriptional induction by fos and jun.
E. You need to spend more time in the lab.
70. Nuclear receptors can regulate gene expression by recruiting transcription factors that promote:
B. Transcript elongation
C. RNA splicing
D. RNA transcription termination
E. All of the above
71. Transcription factor binding sites can be found relative to the transcription start site:
A. Thousands of base pairs upstream .
B. Thousands of base pairs downstream.
C. Associated with introns.
D. At the start site of transcription.
E. All of the above.
72. Some infectious viruses often have promoters resembling eukaryotic promoters most likely because:
A. Viruses and humans have a common origin.
B. Viral DNA can become incorporated and “hide” in DNA from antibody attack.
C. They don’t have genes encoding RNA polymerase and thus enslave the host transcriptional machinery.
D. They need a co-infection with bacteria; which also explains secondary infections after viral infections.
E. None of the above.
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